Lissie is an unincorporated community in Wharton County, Texas, United States. It is located along U.S. Highway 90A in northern Wharton County. According to the Handbook of Texas, the community had an estimated population of 49 in 2000. Although it is unincorporated, Lissie has a post office, with the ZIP code of 77454. Public education in the community of Lissie is provided by the East Bernard Independent School District.