Lisle is a village in DuPage County, Illinois, United States. The population was 21,182 at the 2000 census, and estimated to be 23,135 as of 2008. It is part of the Chicago metropolitan area and the Illinois Technology and Research Corridor. It is also the headquarters of the Nuclear Regulatory Commission Region III. In July 2007, Lisle was ranked #20 in Money magazine's list of "100 Best Places to Live" and #17 on their 2009 list of the "Best Places for the Rich and Single".